Intravenous Exenatide (Byetta) During Surgery

Inclusion Criteria: * Age (\>18 years) * Weight of \> 50 kg and \< 150 kg * Ability to provide informed consent * Elective surgery including: * Cardiac surgery to include elective CABG with or without single or multivalve repair or replacement and/or single or multivalve repair/replacement requiring CPB and sternotomy (to include subjects who are undergoing first time or redo cardiac surgery) * Abdominal aortic aneurysm repair * Carotid endarterectomy * Esophagectomy * Cystectomy * Nephrectomy * If female, subject must be non-lactating, and, if of childbearing potential, must have a negative urine pregnancy test within 24 hours prior to receiving study drug Exclusion Criteria: * Age (\<18 years) * Inability to provide informed consent * History or risk of pancreatitis (e.g. ethanol abuse, gall stones) * Receipt of an investigational drug or device with 30 days prior to surgery * Use of any concomitant medication listed above on the day of surgery * Known allergy to Exenatide, fentanyl, midazolam, isoflurane, propofol, heparin or neuromuscular blockers * Known substance abuse * Surgical procedure other than: Cardiac surgery to include elective CABG with or without single or multivalve repair or replacement and/or single or multivalve repair/ replacement requiring CPB and sternotomy (to include subjects who are undergoing first time or redo cardiac surgery) * Abdominal aortic aneurysm repair * Carotid endarterectomy * Esophagectomy * Cystectomy * Nephrectomy * Insulin d…