Study to Evaluate Analgesic Effect of Intravenous Administration of Kappa Agonist CR845 After Hysterectomy Surgery

Inclusion Criteria: * The patients will have an elective laparoscopic-assisted hysterectomy under general anesthesia. * The patient's preoperative health is graded as the American Society of Anesthesiologists (ASA) risk class of I to III Exclusion Criteria: * The patient has a history of known allergies to opioids * The patient is currently taking opioid analgesics chronically or took opioid analgesics on at least 4 days during the week before surgery. * Patients having additional procedures (such as those involving the bladder) at the same time as the laparoscopic-assisted hysterectomy. * Patients taking short-acting oral analgesics (eg, acetaminophen, aspirin, ibuprofen, ketorolac) within 6 hours before administration of study drug; long-acting nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, naproxen, oxaprozin, piroxicam, celecoxib) within 3 days before administration of study drug; systemic steroids within 72 hours before administration of study drug; or any opioid analgesics or tramadol daily for greater than 10 days of the last 30 days before administration of study drug. * Patients taking the following herbal agents or nutraceuticals within 7 days prior to beginning of the study: chaparral, comfrey, germander, gin bu huan, kava, pennyroyal, skullcap, St. John's wort, or valerian. * Patients with clinically significant cardiovascular disease, or cardiac arrhythmias, or significant major risk factors for cardiovascular disease such as poorly controlled hypertension…