S0702: Osteonecrosis of the Jaw in Patients With Cancer Receiving Zoledronic Acid for Bone Metast… (NCT00874211) | Clinical Trial Compass
CompletedNot Applicable
S0702: Osteonecrosis of the Jaw in Patients With Cancer Receiving Zoledronic Acid for Bone Metastases
United States3,571 participantsStarted 2008-12
Plain-language summary
RATIONALE: Gathering information about how often osteonecrosis of the jaw occurs in patients receiving zoledronic acid for bone metastases may help doctors learn more about the disease and provide the best follow-up care.
PURPOSE: This clinical trial is studying osteonecrosis of the jaw in patients with cancer who are receiving zoledronic acid for bone metastases.
Who can participate
Age range120 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
DISEASE CHARACTERISTICS:
* Participant must have bone metastasis from multiple myeloma, solid tumors, or other malignancy for which intravenous bisphosphonate has clinical indications in the treatment of metastatic bone disease
* Treatment with osteoclast inhibition is clinically indicated
* Must be planning to receive zoledronic acid\* within the next 30 days NOTE: \*Osteoclast inhibition therapy will continue thereafter as clinically indicated.
* No prior diagnosis of osteonecrosis of the jaw
* Patients previously treated with osteoclast inhibition therapy are eligible, provided the following criteria apply:
* Prior osteoclast inhibition for low bone mass (osteoporosis or osteopenia):
* Patients may have previously received at most 3 doses of osteoclast-inhibiting therapy with denosumab, IV ibandronate, pamidronate, or zoledronic acid for low bone mass (osteopenia or osteoporosis) within 3 years prior to registration
* Prior oral bisphosphonate therapy at osteoporosis or osteopenia dosing at any time prior to registration is allowed
* Prior exposures to other medications used to treat low bone mass at osteoporosis or osteopenia dosing are permitted
* Prior osteoclast inhibition for metastatic bone disease (tumor involving bone):
* Patients may have previously received osteoclast-inhibiting therapy with denosumab, ibandronate (oral or IV cancer dosing), pamidronate, or zoledronic acid to treat metastatic bone disease within 180 days prior to registrat…
What they're measuring
1
Diagnosis of confirmed osteonecrosis of the jaw (ONJ)