Double Blind, Crossover Study of Fish Oil [EPA and DHA] for Intractable Partial Seizures

Inclusion Criteria: * Male or female, age 18 - 70 * History of intractable localization related/partial onset seizures and generalized tonic/clonic or tonic seizures defined according to International League Against Epilepsy (ILAE) classification as: * A history compatible with localization related partial epilepsy * A history of generalized tonic clonic or tonic seizures with loss of consciousness * Three or more simple partial, complex partial or tonic-clonic seizures per month * An EEG and/or an MRI consistent with a localization related epilepsy * Evidence of at least three seizures per month for at least two months prior to the study * Exposure to at least one antiepileptic drug at adequate dose Exclusion Criteria: * Significant or progressive medical, cardiac, or other illness * Allergy to fish products or fish oil * History of a coagulation disorder * History of non-epileptic seizures * Consumption of Fish Oil at any time 30 days or less prior to enrollment * Any change in antiepileptic drugs for 30 days or less prior to enrollment * Treatment with Warfarin for 30 days or less prior to enrollment * Previous poor compliance with therapy * Drug or alcohol abuse * Uncountable seizures as a result of seizure clustering, or inadequate supervision if the patient cannot count their own seizures. * Pregnancy