Magna® Mitral Pericardial Bioprostheses Post-Approval Study Protocol

Inclusion Criteria: * The patient requires, as indicated in the preoperative evaluation, a replacement mitral valve. * The patient has signed and dated the subject informed consent form prior to surgery. * The patient is expected to survive the surgery and be discharged. * The patient is geographically stable and agrees to attend follow-up assessments. * The patient is 18 years or older. Exclusion Criteria: * The patient has any known non-cardiac life-threatening disease, which will limit the patient's life expectancy below 1 year. * The patient presents with active endocarditis within the last 3 months. * The patient is pregnant or lactating. * The patient is an intravenous drug abuser. * The patient is currently a prison inmate. * The patient is currently participating in a study of an investigational drug or device. * The patient requires replacement of a native or prosthetic tricuspid or pulmonic valve. * The patient requires replacement of a native or prosthetic aortic valve with a prosthesis other than a commercially available Carpentier-Edwards PERIMOUNT Valve (i.e. models 2700, 2700TFX, 2800, 2800TFX, 2900, 3000, 3000TFX, 3300TFX)\*. * The patient was previously enrolled in the study. * The patient has had prior aortic, tricuspid and/or pulmonary valve surgery, which included implantation of a bioprosthetic valve or mechanical valve that will remain in situ.