Light Therapy for Bipolar Disorder. Efficacy of Light Therapy for Bipolar Depression: A Randomized Controlled Trial

Inclusion Criteria: * Ages 18-65 years * DSM-IV Criteria BD I or II depressive episode, * SIGH-ADS \>20; duration \>2 weeks. * Stable dose antidepressant drug \>8 weeks with concurrent antimanic drug * Controlled thyroid disease * Subjects with preexisting eye diseases will be included. * Able to provide informed consent * Stable minimum dose antimanic drug \>4weeks: lithium 0.5 mEq/L, divalproex Na 50 mcg/mL, olanzapine 5mg daily, carbamazepine 4mg/L; lamotrigine 100mg daily, risperidone 2mg daily, quetiapine 400 mg daily, ziprasidone 10 mg bid, and aripiprazole 5 mg qd. * Stable unchanged psychotherapy for \>16weeks Exclusion Criteria: * The following eye diseases: retinal disease, cataract surgery and lens removal, macular degeneration, * Taking photosensitizing drugs such as phenothiazines (chlorpromazine), antimalarial drugs, melatonin and hypericum. * Acute psychosis (DSM-IV Criteria) * Rapid cycling in the past 1 year * Obsessive compulsive disorder * Alcohol or substance abuse or dependence in the past 6 months. * MRS\>5 * Recent history of a suicide attempt (3 months) or active suicidal Ideation (SIGHADS item H11 \>2) * Beta-adrenergic blockers, exogenous melatonin, chronic NSAIDS