Peanut Allergy Vaccine Study in Healthy and Peanut-allergic Adults

Inclusion Criteria: * Available for the duration of the trial * Ability to perform spirometry maneuvers * Agree to use effective methods of contraception for the duration of the study * For Step 1 participants, regular consumption of at least 5 grams of peanut at least twice per month during the last 6 months prior to study entry * For Step 2 participants, a convincing clinical history of peanut allergy and prick skin test positive to peanut. More information on these criteria can be found in the protocol. Exclusion Criteria: * History of any severe anaphylaxis * Known allergy to hydroxypropyl methylcellulose, glycerol, or phenol * Evidence of clinically significant immunosuppressive neurologic, cardiac, pulmonary, hepatic, rheumatologic, autoimmune, or renal disease * Laboratory evidence of liver or hematologic disease. Pre-existing history of autoimmune or antibody mediated diseases. More information on this criterion can be found in the protocol. * Pre-existing history of autoimmune or antibody mediated diseases. More information on this criterion can be found in the protocol. * Any previous intubation due to allergies or asthma * History of ischemic cardiovascular disease * Uncontrolled hypertension * Significant medical condition that, in the opinion of the investigator, would interfere with the study * Chronic diarrhea * Inability to refrain from anal intercourse for the duration of the trial * Use of rectal medications during the study * Planned rectal procedures fo…