CompletedNot Applicable

Effects of Eszopiclone on Sleep-dependent Learning in Schizophrenia

United States25 participantsStarted 2006-09

Plain-language summary

This study will determine whether eszopiclone will normalize sleep patterns and restore sleep-dependent enhancement of motor skill learning in patients with schizophrenia. The investigators will compare subjects taking a placebo to those taking 3 mg of eszopiclone with regard to: sleep architecture and sleep latency as measured by actigraphy and polysomnography and sleep-dependent motor skill learning.

Who can participate

Age range18 Years – 45 Years

SexALL

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Inclusion Criteria: * Clinically stable outpatients with DSM-IV diagnoses of Schizophrenia Exclusion Criteria: * History of neurologic or psychiatric disease other than schizophrenia * Substance abuse or dependence within the past six months * Other chronic medical conditions that affect sleep * Pregnancy/breast feeding * Hepatic impairment * Treatment with metabolic inhibitors or inducers

What they're measuring

Overnight Change on Finger Tapping Task

Timeframe: Train on Day 3 and Test on Day 4 of study (experimental nights)

Sleep Spindle Density During Stage 2 Sleep as Measured by Polysomnography

Timeframe: during two nights in an inpatient Clinical Research Center

Trial details

NCT IDNCT00833547

SponsorMassachusetts General Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2012-09

Results submitted2014-07-17

View on ClinicalTrials.gov More Schizophrenia trials