A Study to Evaluate the Effect of Testosterone on Muscle Fractional Synthetic Rate (MK-0000-064) (NCT00816712) | Clinical Trial Compass
CompletedPhase 1
A Study to Evaluate the Effect of Testosterone on Muscle Fractional Synthetic Rate (MK-0000-064)
28 participantsStarted 2008-01
Plain-language summary
This is a study to evaluate the use of fractional synthetic rate as an early biomarker of muscle anabolism (muscle build-up).
Who can participate
Age range60 Years – 70 Years
SexMALE
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Subject is weight stable over the past 3 months
* Patient agrees to refrain from consumption of alcohol from 48 hours prior to entering the study
* Subject agrees to follow the study restriction of no caffeine while on study
* Patient agrees to following the meat-free controlled protein weight-maintaining diet
* Patient is willing to avoid strenuous physical activity
* Patient has been a nonsmoker for at least 6 months prior to study start
Exclusion Criteria:
* Subject is currently a regular user of any illicit drugs
* Subject has taken androgenic steroids in the previous 12 months
* Subject has participated in sports events, resistance exercise training or heavy exercise in the previous month
* Subject has prostate cancer
* Subject has a history of cancer except basal-cell tumors
* Subject has been diagnosed with HIV
* Subject has been diagnosed with Hepatitis B or C
* Subject uses certain anti-inflammatory drugs such as ibuprofen, arcoxia or celecoxib
* Subject uses a blood anticoagulant, such as Coumadin (Warfarin) or high doses of aspirin
* Subject is currently taking over the counter supplements such as "muscle builders" or "fat burners"
* Subject has an allergy or hypersensitivity to intramuscular testosterone
* Subject has sciatica
* Subject has donated blood products or has had phlebotomy within 2 months of signing informed consent
* Subject has undergone a surgical procedure within 1 month of signing informed consent
* Subject is currently pa…
What they're measuring
1
Thigh (vastus lateralis) muscle protein fractional synthetic rate one week after dosing with testosterone.