A Clinical Trial to Test a Study Drug in Volunteers Who Develop Asthma Following Exercise

Inclusion Criteria: * Males and females aged 18 to 55 years inclusive. * Female subjects must be of non childbearing potential including pre-menopausal females with documented hysterectomy or double oophorectomy or tubal ligation or postmenopausal defined as 12 months of spontaneous amenorrhea or 6 months of spontaneous amenorrhea with serum FSH levels \> 40 mIU/mL and estradiol \< 40 pg/ml (\<140 pmol/L) or 6 weeks postsurgical bilateral oophorectomy with or without hysterectomy. Hormone replacement therapy (HRT) is permitted for post-menopausal females. * Male subjects must agree to use one of the protocol outlined contraception methods. This criterion must be followed from the time of the first dose of study medication until 3 months after administration of last dose. * Body weight greater than or equal to 50 kg and Body mass index within range of 18.5-35.0 kg/m2 inclusive. * Pre-bronchodilator FEV1 \>70% of predicted at screening. * Exercise induced bronchoconstriction, as defined as a 20-40% decrease in FEV1 compared to baseline immediately following exercise challenge at screening. * Current non-smokers who have not used any tobacco products in the 6-month period preceding the screening visit with a pack history of less than or equal to 10 pack years \[number of pack years = (number of cigarettes per day/20) x number of years smoked\] * Has provided signed and dated written informed consent * Is able to understand and comply with the protocol requirements, instructions…