RecruitingNot Applicable

Establish and Characterize an Acute HIV Infection Cohort in a High Risk Population

Thailand777 participantsStarted 2009-04

Plain-language summary

To describe clinical, immunological, and virological characteristics of persons with acute HIV infection 1. To describe demographics and behavioral risk factors for those identified with acute HIV infection 2. To describe neurocognitive function and neuroimaging findings in acute HIV infection as well as describe immune response, HIV-1 genotypes and sequences in the cerebrospinal fluid. 3. To describe the number and characteristics of sexual contacts 4. To describe the willingness of acute HIV-infected subjects to allow the tracking of their sexual contacts for voluntary HIV counseling and testing (VCT) 5. To describe immune response, HIV-1 genotypes and sequences in the genital compartment 6. To describe T cell depletion in the gut mucosa in acute HIV infection and describe the changes in gut T cell during follow up 7. To archive samples for future investigations including determination of viral evolution, and cell-mediated and humoral immune responses in peripheral blood and mucosal compartments

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Age \>18 years old
✓. Have protocol-defined acute HIV-1 infection (Tested 4th generation HIV EIA negative and NAT positive or tested 4th generation HIV EIA positive, negative by less sensitive EIA and NAT positive)
✓. Understand the study and sign informed consent form. Persons who cannot read will have the consent form read to them by a study staff and they can give informed consent by using thumb print.
✓. Availability for follow-up for the planned study duration

Exclusion criteria

✕. Persons who have a history of a medical or psychiatric disorder by investigator's interview and physical examination according to standard practices, that in the judgment of the investigator(s), would interfere with or serve as a contraindication to adherence to the study protocol or ability to give informed consent.
✕. Female participants who are pregnant at the time of screening

What they're measuring

Number of HIV and non-HIV related clinical events

Timeframe: It will take approximately 72 months to complete the study. The screening and enrollment is 48 months.

Trial details

NCT IDNCT00796146

SponsorSEARCH Research Foundation

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2033-07

Contact for this trial

Nittaya Phanuphak, MD, PhD

6621605371 Nittaya.p@ihri.org

View on ClinicalTrials.gov More Acute HIV Infection trials