Efficacy Study of Prucalopride to Treat Chronic Intestinal Pseudo-Obstruction (CIP)

Inclusion Criteria: * Aged ≥ 18 years; * A history of chronic pseudo-obstruction for at least 3 months; * Subjects with chronic idiopathic pseudo-obstruction or chronic pseudo-obstruction secondary to scleroderma or intestinal polyneuropathy; * CIP had been diagnosed by a Barium-imaging study showing the presence of dilatation of any part of the small bowel (with or without the presence of large bowel dilatation); Exclusion Criteria: * Subjects with organic obstructing lesions causing intestinal obstruction; * Current uncontrolled cardiovascular or lung disease, neurologic or psychiatric disorders (including substance abuse but with the exception of nicotin), alcoholism, cancer or AIDS and endocrine disorder; * Impaired renal function * A serum amylase, a serum glutamic-oxaloacetic transaminase (SGOT) or a serum glutamic-pyruvic transaminase (SGPT)concentration of \> 2 times the normal limit; * Laboratory values outside the reference range of the laboratory, unless explained by the disease or felt by the investigator to be clinically unimportant; * Use of disallowed concomitant therapy; * Female subjects who were pregnant or wished to become pregnant during the course of the trial or who were lactating;