CompletedNot Applicable

Serum Concentration of Lidocaine After Local Injection During Mohs Micrographic Surgery

United States19 participantsStarted 2007-09

Plain-language summary

The primary objective of this study is to (1) determine whether local injection of lidocaine used during Mohs surgery will elevate serum lidocaine concentrations to a level that could cause systemic symptoms and (2) determine whether sustained high levels of serum lidocaine occur after intralesional anesthesia on the face and neck. This study is a cross-sectional study of 10 subjects with basal cell carcinoma or squamous cell carcinoma of the face or neck requiring Mohs micrographic surgery. The study will consist of a brief questionnaire and blood draws during their Moh's surgical procedure.

Who can participate

Age range18 Years – 75 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria * Age: 18-75 * Basal cell carcinoma or squamous cell carcinoma of the head or neck * Subjects are in good health * Subjects that have the willingness and the ability to understand and provide informed consent for the use of their blood and communicate with the investigator Exclusion Criteria * Lidocaine sensitivity * Bleeding disorder * Pregnancy * Medical conditions which would impair hepatic blood flow: congestive heart failure, liver dysfunction, peripheral vascular disease. * Subjects who are unable to understand the protocol or to give informed consent * Subjects with mental illness

What they're measuring

The Number of Subjects With Detectable Serum Lidocaine Concentrations (<0.1 ug/mL) at Each Blood Draw.

Timeframe: 6 hours

Trial details

NCT IDNCT00793169

SponsorNorthwestern University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2008-07

Results submitted2010-09-30

View on ClinicalTrials.gov More Basal Cell Carcinoma trials