This is a double-blind 3-arm randomized clinical trial to determine whether higher dose oxytocin regimens (compared to the standard regimen) reduce the frequency of uterine atony and postpartum hemorrhage after vaginal delivery. Uterine atony is a loss of tone in the uterine musculature which can cause acute postpartum hemorrhage, which is the major cause of maternal mortality worldwide. Oxytocin is routinely administered postpartum in the US and effectively reduces uterine atony. The optimal dose of oxytocin for vaginal delivery is not known.
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Number of Subjects Reporting Uterine Atony or Postpartum Hemorrhage Requiring Medical (Medication or Blood Transfusion), Surgical or Other Interventional Treatment
Timeframe: baseline to discharge (2 - 3 days)
Women in Each Group With Risk Factors for Atony or Postpartum Hemorrhage
Timeframe: Initial hospital discharge (2-3 days)
Risk to Using Increasing Doses of Oxytocin Based on Pre-specified Risk Factors
Timeframe: baseline to discharge (2-3 days)