This is a Phase 1 study evaluating the safety of ABT-263 administered in combination with rituximab in participants with CD20-positive lymphoproliferative disorders. The extension portion of the study will allow active participants to continue to receive ABT-263 for up to 14 years after the last participant transitions with quarterly study evaluations.
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Extension Study: Continued assessment of the safety profile of ABT-263 when administered in combination with rituximab
Timeframe: Safety will be assessed until the participant discontinues the extension portion of the study.
Assess the safety profile and characterize the pharmacokinetics of ABT-263 when administered in combination with rituximab
Timeframe: Safety and pharmacokinetics will be assessed until the participant discontinues the study or transitions to the extension portion of the study (whichever comes first).
Determination of dose limiting toxicity (DLT) and maximum tolerated dose (MTD) when ABT-263 is administered in combination with rituximab
Timeframe: DLTs and MTD will be assessed after all participants in a dose level have completed the lead-in period plus 28 days if dosing with ABT-263 and rituximab