CompletedPhase 3

Vitamin K Supplement for Inhibition of the Progress in Aortic Valve Calcification

Germany99 participantsStarted 2010-01

Plain-language summary

In this mono-center,open,three-armes, controlled, randomized phase I study the progress of aortic valve calcification with and without vitamin K supplementation will be investgated. This will be done by means of measurements of concentrations from osteocalcine and MPG in blood serum, echocardiography, cardiac computed tomography and cardiac MRI

Who can participate

Age range50 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * aortic valve calcification,verified by echocardiography Exclusion Criteria: * chronic or acute intestinal diseases * terminal renal failure * allergic reaction on soya containing products * recent additional intake of vitamin K * oral anticoagulation with vitamin K antagonists (Marcoumar) * systemic therapy with corticosteroids * anamnestic venous thrombosis (pelvet or legs)or embolization of lung arteria * pregnant or breastfeeding women * persons without mental ability or capacity to understand and follow the instructions of the investigator * women of childbearing age without safe contraceptional devices * minority

What they're measuring

Decrease of aortic valve calcification by activation of the calcification inhibiting protein MGP by means of additional intake of vitamin K

Timeframe: 18 months

Trial details

NCT IDNCT00785109

SponsorRWTH Aachen University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2015-08

View on ClinicalTrials.gov More Aortic Valve Calcification trials