The Effects of Omega-3 Fatty Acids on Aspirin Resistance

Inclusion Criteria: * Willing to participate by providing informed consent and committing to complete the study. This includes adhering to the study diet. * No chronic disease by history and based on a complete blood count and comprehensive metabolic profile. * Commitment to not taking aspirin, non-steroidal anti-inflammatory medications, and to limit fish intake to ≤2 meals during the 7 days prior to each CRC study period. They will also need to abstain from taking a list of over-the-counter medications that include aspirin. For the duration of the study, they will also be asked to abstain from taking fish and flax seed oil supplements. Exclusion Criteria: * Reports the presence of chronic disease (e.g. cardiovascular, renal, hepatic, neurodegenerative, neoplastic, metabolic {diabetes}, hypertension). * Reports taking a systemic medication chronically. * History of serious adverse reaction or allergy to aspirin or fish oil. * Baseline platelet count \<100 000 or \>500 000, hematocrit \<30%, or white blood cell count \>20 000. * Any abnormality from a screening CBC and complete blood count that suggests acute or chronic disease. * Nicotine user. * History of alcohol abuse * Pregnancy by history or urine/serum pregnancy test * History of intestinal malabsorption syndrome including gastric bypass surgery