Study of Atorvastatin Dose Dependent Reduction of Proteinuria

Inclusion Criteria: * Age of 18 and over * Stage 3 or 4 chronic kidney disease (modified MDRD) * proteinuria of \> 1g/d on ACEi and/or ARB, or proteinuria of \> 1g/d with intolerance or contraindication to ACEi and/or ARB * blood pressure \< 130/80 mmHg or \< 140/90 mmHg in patients with five or more antihypertensive drugs * stable renal function Exclusion Criteria: * rapid progression of renal failure * immunosuppressive therapy within the past 3 months * need a renal replacement therapy within 8 months * definite history of chronic liver disease, or abnormal liver function * evidence of active inflammatory muscle disease * definite previous adverse reaction to a statin * concurrent treatment with a contraindicated drug (fibrate, macrolide antibiotic, systemic use of imidazole or triazole antifungals, protease-inhibitors, ciclosporin) * child bearing potential * known to be poorly compliant with clinic visits or prescribed medication