Safety, Efficacy, and Side Effects Study of Interventional Cryotherapy in the Pleural Space("ICE PLS")

Inclusion Criteria: * 18 years of age * Deemed a candidate for cryotherapy based on physician physical or medical history review * Deemed operable based on institutional criteria * Able to sign informed consent * Documented lung or other visceral cancer with pleural involvement. * WBC \> 4,000/mm3, platelets \>100,000mm3 * Physically well enough to undergo moderate sedation and pleuroscopy * Female patients must be HCG negative * There should be direct evidence of disease progression despite treatment in previously treated patients Exclusion Criteria: * Pregnant or nursing * Planning to sire a child while enrolled in the study * Known history of unresolved drug or alcohol dependency that would limit ability to comprehend or follow instructions related to informed consent, post-treatment instructions, or follow-up guidelines. * Refusal or inability to give consent. * Concurrent chemotherapy. * Medical contraindication or potential problem that would preclude study participation * Concurrent participation in other experimental studies * Uncontrolled coagulopathy or bleeding diathesis * Serious medical illness, including: * Uncontrolled congestive heart failure * Uncontrolled angina * Myocardial infarction * Cerebrovascular accident within 6 months prior to study entry