The primary objective of this study is to evaluate the safety and tolerability of SK\&F-105517-D in japanese patients with chronic heart failure.
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Number of Participants With Adverse Events by Severity From Week 0 Through Week 8 (CRV-IR) or Week 14 (SK&F-105517-D)
Timeframe: Treatment Period from Week 0 (Baseline) to Week 8 and 1-week Follow-up Period (Week 9) for CRV-IR; Treatment Period from Week 0 (Baseline) to Week 14 and 1-week Follow-up Period (Week 15) for SK&F-105517-D
Mean Change From Baseline in Albumin and Total Protein at Week 8
Timeframe: Baseline and Week 8
Mean Change From Baseline in Alkaline Phosphatase, Alanine Aminotransferase, Aspartate Aminotransferase, Creatine Kinase, and Gamma Glutamyl Transferase at Week 8
Timeframe: Baseline and Week 8
Mean Change From Baseline in Amylase at Week 8
Timeframe: Baseline and Week 8
Mean Change From Baseline in Total Bilirubin, Creatinine, and Uric Acid at Week 8
Timeframe: Baseline and Week 8
Mean Change From Baseline in Calcium, Chloride, Glucose, Potassium, Sodium, and Urea/Blood Urea Nitrogen at Week 8
Timeframe: Baseline and Week 8
Mean Change From Baseline in Creatine Kinase BB Percentage, Creatine Kinase MB Percentage, and Creatine Kinase MM Percentage at Week 8
Timeframe: Baseline and Week 8
Mean Change From Baseline in Each Type of White Blood Cell (WBC) (Basophils, Eosinophils, Lymphocytes, Monocytes, and Total Neutrophils) at Week 8
Timeframe: Baseline and Week 8
Mean Change From Baseline in Hemoglobin and Mean Corpuscular Hemoglobin Concentration at Week 8
Timeframe: Baseline and Week 8
Mean Change From Baseline in Hematocrit at Week 8
Timeframe: Baseline and Week 8
Mean Change From Baseline in Platelet Count and White Blood Cell Count at Week 8
Timeframe: Baseline and Week 8
Mean Change From Baseline in Red Blood Cell Count at Week 8
Timeframe: Baseline and Week 8
Mean Change From Baseline in Mean Corpuscular Hemoglobin at Week 8
Timeframe: Baseline and Week 8
Mean Change From Baseline in Mean Corpuscular Volume at Week 8
Timeframe: Baseline and Week 8
Number of Participants With the Indicated Urinalysis Dipstick Results at Baseline and Week 8
Timeframe: Baseline and Week 8
Mean Change From Baseline in Systolic Blood Pressure and Diastolic Blood Pressure at Week 8
Timeframe: Baseline and Week 8
Mean Change From Baseline in Heart Rate at Week 8
Timeframe: Baseline and Week 8
Mean Change From Baseline in Weight at Week 8
Timeframe: Baseline and Week 8
Number of Participants With the Indicated Electrocardiogram Findings at Baseline and Week 8
Timeframe: Baseline and Week 8
Cardiothoracic Ratio at Baseline and Week 8
Timeframe: Baseline and Week 8