Efficacy and Safety of 3 Doses of HL10 Given at Fixed Time Intervals Compared to Standard Therapy

Inclusion Criteria: * Patients intubated and on mechanical ventilation * Patients with Acute Lung Injury defined as (a, b, c and d are all applicable): a: PaO2/FiO2 \< or equal to 300 mmHg (40.0 kPa) (regardless of PEEP level), b: Acute onset, c: Pulmonary artery wedge pressure \< or equal to 18 mmHg when measured or no clinical evidence of left atrial hypertension, d: Bilateral infiltrates seen on frontal chest radiograph * Less than 60 hours from onset of the present period of mechanical ventilation to 1st instillation * Expected to continue on mechanical ventilation for more than 24 hours * 18 years of age or older * Following receipt of verbal and written information about the trial, the patient or legally acceptable representative must provide signed and dated informed consent before any trial related activity is carried out Exclusion Criteria: * Current diagnosis of acute bronchial asthma attack * History of or clinical suspicion of lung fibrosis * Current diagnosis of suspected pulmonary thrombo-embolism * Patients on daily medication for chronic obstructive pulmonary disease at time of admission to ICU * Patients who have received mechanical ventilation for more than 48 hours continuously within 1 month prior to the present period of mechanical ventilation * Patients with pneumonectomy or lobectomy * Patients with untreated pneumothorax at time of instillation * Patients having tracheostomy at time of instillation * Patients who have had surgical procedures under g…