Safety Study of Human Recombinant Tissue Non-Specific Alkaline Phosphatase Fusion Protein Asfotase Alfa in Adults With Hypophosphatasia (HPP)

Inclusion Criteria: In order to qualify for participation, patients must meet all of the following criteria: * Patients must provide written informed consent, including privacy authorization, prior to participation. * Women of childbearing potential must sign the Women of Childbearing Potential Addendum and must be using an acceptable method of birth control. Women considered not of childbearing potential must be surgically sterile (total hysterectomy, bilateral salpingo-oophorectomy, or tubal ligation) or post-menopausal, which is defined as a complete cessation of menstruation for at least one year after the age of 45 years. All women must have a serum pregnancy test conducted at Screening prior to enrollment and the results must be negative. * Be between 18 and 80 years of age at the time of consent * Patients must be medically stable in the opinion of the Investigator. * Patients must be willing to comply with study procedures and the visit schedule. * Pre-established clinical diagnosis of HPP as indicated by: * a. Serum alkaline phosphatase at least 3 SD below the mean for age * b. Radiologic evidence of osteopenia or osteomalacia * c. Two or more HPP-related findings: * i. Plasma pyridoxal 5'-phosphate at least 2.5 SD above the mean (no vitamin B6 administered for at least 1 week prior to determination * ii. History of rickets * iii. History of premature loss of deciduous teeth * iv. Bone deformity consistent with osteomalacia or past history o…