Diagnostic Accuracy of Multi-Detector Spiral Computed Tomography Angiography Using 64 Detectors

Inclusion Criteria: * Male or female patients, age 40 years or greater. * Women of child bearing potential must demonstrate a negative pregnancy test within 24 hours of the study MDCT. * Suspected coronary artery disease (i.e. symptoms, signs) with a clinical indication for coronary angiography; and planned coronary angiography within the next 30 days. * Able to understand and willing to sign informed consent. Exclusion Criteria: * Known allergy to iodinated contrast media * History of contrast-induced nephropathy * History of multiple myeloma or previous organ transplantation * Elevated serum creatinine (\> 1.5mg/dl) OR calculated creatinine clearance of \< 60 ml/min (using the Cockcroft-Gault formula * Atrial fibrillation or uncontrolled tachyarrhythmia, or heart block * Evidence of severe symptomatic heart failure; moderate or severe aortic stenosis * Previous coronary artery bypass or other cardiac surgery * Coronary artery intervention within the last 6 months * Intolerance or contraindication to beta-blockers * Body Mass Index \> 40.