Compassionate Use of an Intravenous Fish Oil Emulsion in the Treatment of Liver Injury in Infants

Inclusion Criteria: * Be greater than 14 days old and less than 5 years old * Conjugated bilirubin greater than 2 mg/dL. * Be expected to require intravenous nutrition for at least an additional 28 days Exclusion Criteria: * Have a congenitally lethal condition (e.g. Trisomy 13). * Have clinically severe bleeding not able to be managed with routine measures. * Have evidence of a viral hepatitis or primary liver disease as the primary etiology of their cholestasis. * Have other health problems such that survival is extremely unlikely even if the infant's cholestasis improves. Home Use of Omegaven®: In order for a subject to receive the Omegaven® at home through a home health care agency, subjects will first be required to be admitted to Texas Children's Hospital for 72 hours in initiate the administration of the Omegaven®. This will allow time for observation of any unexpected side effects and for parents to be provided education on home TPN and Omegaven®. If a subject has already received Omegaven® either at TCH or at another hospital, they will not be required to be admitted for the 72 hour inpatient admission prior to starting Omegaven® at home. Parent training will occur during the previous hospital admission and will continue through the TCH Pediatric Intestinal Rehabilitation Clinic. Outpatient Monitoring: After the initial evaluation by the TCH Pediatric Intestinal Rehabilitation Clinic physicians, subjects will return to the clinic for routine follow-up. Subjec…