This study is being done to find out if medicines that affect a neurotransmitter (chemical messenger) in the brain called adenosine improve behavioral problems that are related to drug abuse. Another purpose of the study is to find out how genes related to adenosine change how people respond to these medicines. More information about how these medicines change behaviors may be helpful to come up with new treatments for drug abuse.
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Visual Analog Scale Subjective Rating of Drug Effects
Timeframe: Immediately after dose
Systolic and Diastolic Blood Pressure
Timeframe: Average across 7 time points: Immediately after dose and every 30 minutes for 3 hours
Heart Rate
Timeframe: Average across 7 time points: Immediately after dose and every 30 minutes for 3 hours
Addiction Research Center Inventory Subjective Rating of Drug Effects
Timeframe: Immediately after dose
Drug Effects Questionnaire Rating of Subjective Ratings of Drug Effects
Timeframe: Immediately after dose