Safety of N-acetylcysteine in Maternal Chorioamnionitis (NAC in Chorio)

Inclusion Criteria: Participants had all of the following to qualify: * Chorioamnionitis, defined as either 1) clinical diagnosis of choriomanionitis 2) maternal fever greater than or equal to 100 degrees F in the presence of rupture of membranes or 2 of the following: uterine tenderness, maternal WBC \> 15,000 cells/mm, fetal tachycardia \> 160 bpm, malodorous amniotic fluid, or in preterm group only, rupture of membranes and active preterm labor. * Gestational age ≥ 24 completed weeks, by first trimester ultrasound or date of last menstrual period. * No greater than 4 hours from onset of fever or diagnosis. Exclusion Criteria: Participants had none of the following: * Asthma, steroid-dependent * Clinical sepsis, whether viral or bacterial in nature, defined as fever with signs of cardiovascular compromise in mother (blood pressure \< 90/50, heart rate \> 120 bpm, need for oxygen due to maternal saturations below 92%, pneumonia, pyelonephritis, or meningitis) * Seizure disorder * Fetal weight or biparietal diameter less than the 10th% for gestational age * Suspected major genetic or congenital abnormality * Fetal distress which demands immediate delivery (poor fetal biophysical profile, late decelerations, sinusoidal fetal heart rate pattern) * Participation in another therapeutic clinical trial