Effectiveness of the Eradication of Helicobacter Pylori and an Inhibitor of Pump With Proton Vers… (NCT00713947) | Clinical Trial Compass
WithdrawnPhase 4
Effectiveness of the Eradication of Helicobacter Pylori and an Inhibitor of Pump With Proton Versus Control
Stopped: no inclusion
France0Started 2008-04
Plain-language summary
Low dose of aspirin is the main cause of gastro-duodenal ulcer. The best prevention is not definite particularly in patients without history of ulcer and infected by H. pylori.The aim of the study is to evaluate the gastric damage induced by aspirin in patients with H. pylori infection but who have any history of ulcer.
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients of more than 18 years old
* Coronarography or coronary imaging or supra-aortic arterial trunks ultrasound examination performed since less 7 months and having at least an arterial vascular stenosis
* Indication for aspirin treatment for at least 12 months (at the moment of the visit of inclusion) at a posology from 80 to 125 mg per day. The treatment must be prescribed since less than 7 months.
* Patient who had since less 7 month a positive Helicobacter Pylori serology.
* For the women in age to procreate, effective mode of contraception (oral contraception, surgical sterilization, coil)
* Patient having given an informed consent according to recommendation of the CPP (institutional ethical committee).
Exclusion Criteria:
* treatment by anti-coagulant, whatever its nature and its posology, by proton pump inhibitor, H2 receptor antagonists or antiacid having to be continued beyond the day of inclusion
* Treatment by methotrexate in progress or stopped since less 3 months.
* Time of more 7 months enters the beginning of the treatment by aspirin and the visit of inclusion
* Treatment by NSAID (even occasional or self medication) under or stopped since less 3 months.
* Treatment by anti-platelet drug (clopidogrel, ticlopidine, flurbiprofen, dipyridamole or antagonist of receptor GPIIb/IIIa) in progress or stopped since less than 10 days.
* Patient with a serious pathology compromising survival in the 6 month to come.
* Patient with renal or resp…
What they're measuring
1
Measure: severity of the ulcerated gastric lesions induced by the aspirin