Efficacy of Pioglitazone on Bone Metabolism in Postmenopausal Women With Impaired Fasting Glucose.

Inclusion Criteria: * Is female and has not experienced menses for at least 5 years. * Has a Fasting Plasma Glucose level greater than or equal to 100 and less than 126 mg/dL or a 2-hour post-oral glucose tolerance test greater than or equal to 140 and less than or equal to 199 mg/dL at Screening. * Has a body mass index greater than or equal to 16 and less than or equal to 40 kg/m2 and weighs less than 300 pounds (approximately 136 kilograms). * Agrees to take daily supplements of Vitamin D (a minimum of 800 IU daily) and calcium (a minimum of 1000 mg daily) during the treatment and wash-out periods. * Has clinical laboratory evaluations (including clinical chemistry, hematology, and complete urinalysis \[fasted for at least 8 hours\]) within the reference range for the testing laboratory unless the results are deemed not clinically significant by the investigator or sponsor. * Is in good health as determined by the physician (ie, via medical history and physical examination) at Screening. Exclusion Criteria: * Has a fasting triglyceride level greater than 500 mg/dL. * Has a hemoglobinopathy causing anemia or interfering with glycosylated hemoglobin assays. * Has an alanine transaminase level greater than or equal to 2.5 times the upper limit of normal, active liver disease or jaundice. * Has Vitamin D (25-OH-D) less than 20 ng/mL. * Has Baseline Bone Mineral Density defined as a T-score less than -2.0 at the total hip, spine, or femoral neck based on Caucasian reference …