Mechanisms of Exercise-induced Bronchospasm (NCT00701025) | Clinical Trial Compass
CompletedNot Applicable
Mechanisms of Exercise-induced Bronchospasm
United States70 participantsStarted 2008-04
Plain-language summary
The term exercise-induced bronchospasm (EIB) describes acute, transient airway narrowing that occurs during, and most often after, exercise. Manifestations of EIB can range from mild impairment of performance to severe bronchospasm and respiratory failure.
The pathogenesis of EIB remains controversial and the role of airway inflammation has not yet been definitively characterized. We plan on comparing markers of inflammation in asthmatic participants with and without EIB at baseline and after bronchoprovocation with eucapnic voluntary hyperventilation testing (EVH). We also will collect demographic information as well as information about asthma control and exercise habits.
Who can participate
Age range18 Years – 70 Years
SexALL
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Inclusion criteria
✓. Men and women
✓. History of physician-diagnosed asthma
✓. Age between 18 and 70 years old.
✓. Females of childbearing age may participate only if they have a negative pregnancy test, are non-lactating, and agree to practice an adequate birth control method (abstinence, combination barrier and spermicide, or hormonal) for the duration of the study. These requirements for contraception also apply to women who may have irregular or absent menstrual periods.
✓. Non-smoker for 6 months or longer
✓. Less than 10 pack year (number of packs per day (x) years of smoking = pack years) smoking history
Exclusion criteria
✕. Objective evidence of severe lung impairment on pulmonary function testing performed at the beginning of the study.
✕. Participation in another interventional research trial
✕. Unable to provide consent
What they're measuring
1
To compare markers of inflammation in asthmatic participants with and without EIB at baseline and after bronchoprovocation with eucapnic voluntary hyperventilation testing (EVH).