Effectiveness of Olanzapine Versus Placebo in Treating Outpatients With Anorexia Nervosa

Inclusion Criteria: * Meets DSM-IV criteria (not including amenorrhea) for AN * Body mass index (BMI) less than 19 kg/m2 and greater than 14 kg/m2 * Patient (or family if the patient is a minor) refuses hospitalization * Free of psychotropic medication (4 weeks medication free for fluoxetine and antipsychotic medication; 2 weeks medication free for all others) OR on a stable dose of an SSRI or SNRI (venlafaxine) for 4 weeks before study entry * Prior treatment of AN Exclusion Criteria: * Any medical or psychiatric problem requiring urgent attention and/or any significant comorbid illness not likely to benefit from proposed treatments * Allergy to olanzapine * Significant orthostatic high blood pressure * Recent commencement of psychotherapy in the community * Diabetes mellitus, with a fasting serum glucose greater than 120 mg/dL or nonfasting serum glucose greater than 140 mg/dL * Known history of current or past jaundice * Known history of narrow angle glaucoma * Active substance abuse or dependence * Schizophrenia, schizophreniform disorder, or bipolar illness * Movement disorder or presence of tics * History of tardive dyskinesia * History of seizures * Pregnant