Safety Study of CALAA-01 to Treat Solid Tumor Cancers

Inclusion Criteria include: * Subjects must be at least eighteen (18) years of age. * Subjects must have the following: * Histologically- or cytologically-confirmed solid malignancy that is measurable or non-measurable recurrent or metastatic disease (i.e., evaluable; e.g., cytologically or radiologically-detectable disease, markers, etc.) * Measurable disease is metastatic or unresectable * Standard curative or palliative measures do not exist, are no longer effective, or are unlikely to be effective. * Subjects must have tumors that have recurred after previous surgery and/or radiation. * Subjects must have received prior adjuvant, neoadjuvant, or any other therapy for metastatic disease. No restriction is placed on the number of cycles or regimens of prior therapy. * Subjects must have fully recovered from diagnostic or therapeutic surgery (i.e., complete wound healing). * Subjects must have fully recovered from prior radiotherapy for local symptom palliation. * Subjects must have recovered from the toxic effects of prior therapy. * Women and men of child-bearing/conceiving potential must be willing to use highly effective contraceptive methods during the course of the study. Any female who is not sexually active must agree to begin using highly effective contraceptive methods if she becomes sexually active during the study. Females who are post-menopausal (i.e., no longer menstruating) must have been so for two (2) years. * Females of child-bearing potential (e.g.…