Transoral Gastric Volume Reduction as an Intervention for Weight Management

Inclusion Criteria: * Male, Female; ages \>18yrs - £ 60 yrs * BMI 30-45 kg/m2 * History of obesity for 5 yrs; attempts at weight control ineffective * Weight stable * Willing to comply with study requirements * Agrees to not have any additional weight loss surgery, reconstructive surgery or liposuction for one year following procedure * Sign informed consent form Exclusion Criteria: * Women of childbearing age not practicing effective birth control method or pregnant or lactating * Mallampati score = 4 * Uncontrolled hypothyroidism * Previous interventional/surgical treatment of obesity; any prior gastric surgery * History of diabetes for \> 10 yrs or difficult to control diabetes * Presence of hiatal hernia * Congenital or acquired anomalies of the GI tract * Severe cardiovascular, cerebrovascular, or cardiopulmonary disease * Chronic or acute upper gastrointestinal bleeding conditions * Helicobacter pylori positive * Immunocompromised * Subjects with eating disorders * Acute or chronic infection * Significant movement limitations * Not a candidate for conscious or general anesthesia * Active substance abuse * Life expectancy \< 2 years * Enrolled in another investigational drug or device trial that has not completed the primary endpoint or that clinically interferes with this study