Immunogenicity, Safety and Tolerability of the Typhoid Fever Vaccine Candidate M01ZH09 in Healthy Adults

Inclusion Criteria: * healthy adult subjects aged 18 to 50 years inclusive, who are able and willing to give informed consent, following a detailed explanation of participation in protocol * available for the duration of the study and available for scheduled and potential additional visits Exclusion Criteria: * women who are pregnant, breast-feeding or of childbearing potential and unwilling to use a reliable method of contraception throughout the study period * history of anaphylactic shock following vaccination by any route have phenylketonuria * hypersensitivity to any component of the vaccine or are hypersensitive to two of the following antibiotics: ciprofloxacin, azithromycin, ampicillin, trimethoprim sulfamethoxazole * received antibiotic medication within 14 days prior to dosing * received any vaccine within 4 weeks prior to dosing or plan to receive a vaccine within 4 weeks after dosing * received any vaccine against Salmonella typhi (licensed or investigational) or ever suffered from typhoid fever * subjects who test positive for hepatitis B, hepatitis C, HIV or human leucocyte antigen B-27 * known or suspected history of liver or active gall bladder disease, ongoing gastro-intestinal disease or abnormality * commercial food handlers or health care workers with direct contact with high risk patients or who have household contacts with immuno-compromised individuals, pregnant women or children less than 2 years of age * subjects who have a clinically significant a…