A Phase IIa Proof-of-concept Study of NC-503 in Patients With Type II Diabetes

Inclusion Criteria: * Age and gender eligibility: 30 years and older * Diagnosis of Type 2 diabetes mellitus * Patients treated with a stable therapeutic dose of either metformin, a sulfonylurea agent, or metformin in combination with a sulfonylurea agent for a minimum period of 3 months prior to the Screening visit * Patients must have HbA1C level between 7.0-10.0 %, inclusively at screening * The participant must have central obesity (Waist circumference) defined per country/ethnic group: Europids: men ≥ 94 cm, women ≥ 80 cm; South Asian, Chinese \& Japanese: men ≥ 90 cm, women ≥ 80 cm; and any one of the following metabolic syndrome characteristics at screening: * Reduced HDL cholesterol ≤ 1.0 mmol/L * Hypertriglyceridemia ≥ 1.7 mmol/L or treatment for dyslipidemia * Hypertension: ≥ 130/85 mm Hg blood pressure or treatment with antihypertensive medication. * Patients must have a Glomerular Filtration Rate (GFR) of ≥ 60 mL/min, and no history of dialysis. Exclusion Criteria: * Patients having received insulin, thiazolidinediones (TZDs) or non-thiazolidinedione hypoglycemic agents other than metformin or sulfonylurea agents within three months prior to screening * Has had, within the last 6 months, evidence of significant heart disease or stroke, including myocardial infarction, unstable angina, coronary bypass and/or percutaneous transluminal coronary angioplasty (PTCA), congestive heart failure (New York Heart Association Class III-IV), or severe ischemic disease * Pati…