Study Comparing a Soybean Oil-Based With an Olive Oil-Based Lipid Emulsion in ICU Patients Requiring TPN

Inclusion criteria: * Age: 18 - 80 years when initiating PN * In medical/surgical ICU * Has central venous access to administer PN * Anticipated to receive PN ≥ 5 days Exclusion criteria: * Enrolled in an investigative study within the last 30 days prior to study entry * Female patients: pregnant or breast feeding * Has clinical sepsis (defined as mean arterial pressure (MAP) \< 60 mmHg on ≥ 2 occasions and unstable BP despite pressor support) within 24 hours prior to study entry * Has known cirrhosis or total bilirubin ≥ 10.0 mg/dL * Has chronic renal failure (defined as requirement for hemodialysis or peritoneal dialysis therapy), or creatinine ≥ 3.5 mg/dL without continuous renal replacement therapy (CRRT), or requires acute post-operative dialysis * Has an active malignancy (defined as requiring chemotherapy, radiation, and/or surgical intervention within 90 days prior to study entry) (excluding non-melanoma skin cancer) * Has known AIDS * Has a terminal illness (life expectancy \< 7 days) * Has undergone organ transplantation * Has received PN with lipid within 48 hours prior to study entry * Has mental disability to understand the scope and possible consequences of the study and the legally authorized representative is unavailable * Has a baseline serum triglyceride \> 400 mg/dL