Over Active Bladder Instillation Study - Botox

Inclusion Criteria: * Female patient aged 18 years or older * No evidence of stress urinary incontinence on physical examination or urodynamics * Patients who have failed prior drug therapy for overactive bladder or detrusor hyperreflexia * Patients with symptoms and signs of OAB, detrusor hyperreflexia, urinary urgency, urinary urge incontinence. * Patient who is mentally competent with the ability to understand and comply with the requirements of the study * Patient who agrees to be available for the follow-up evaluations as required by the protocol * Patient who has given signed informed consent Exclusion Criteria: * Patient with Post-Void Residual Urine (PVRU) greater than 100 ml on repeated measures. (Patient with a single PVRU of \>100 ml and followed by two consecutive PVRU measurements of \<100 ml may be included in the study) * Patient with greater than vesicoureteral reflux grade 1, interstitial cystitis, genitourinary fistulae * Patient with pelvic organ prolapse stage III or IV, i.e. the most distal part of the prolapse protruding more than 1 cm beyond the hymen (\>+1), at straining * Patient with un-investigated hematuria * Patient with lower tract genitourinary malignancies * Patient on current medication for stress urinary incontinence, such as alpha-adrenergic agonists or duloxetine, within three weeks prior to completing the baseline Bladder Diary (estrogen therapy on a stable dose for at least two months prior to study start is allowed) * Patient with ong…