Combination Chemotherapy in Treating Patients With Sarcoma (NCT00662233) | Clinical Trial Compass
CompletedEarly Phase 1
Combination Chemotherapy in Treating Patients With Sarcoma
United States28 participantsStarted 1991-10
Plain-language summary
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells.
PURPOSE: This clinical trial is studying how well combination chemotherapy works in treating patients with sarcoma.
Who can participate
Age range21 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
DISEASE CHARACTERISTICS:
* Diagnosis of any of the following:
* High-grade nonmetastatic, nonrhabdomyosarcomatous soft tissue sarcomas (excluding undifferentiated sarcoma and Ewing sarcoma)
* Small round cell sarcomas (excluding primitive neuroectodermal tumors of soft tissue) (closed to accrual)
* Undifferentiated sarcomas (closed to accrual)
* Rhabdomyosarcomas (excluding non-parameningeal head tumors, vaginal or stage I paratesticular) (closed to accrual)
* All alveolar rhabdomyosarcomas (closed to accrual)
* No evidence distant metastatic disease (i.e., lung, bone, bone marrow)
* Local or regional nodal disease allowed
* No spindle cell tumors of bone
* Primary lesions do not have to be resectable
PATIENT CHARACTERISTICS:
* Creatinine ā¤1.5 mg/dL OR creatinine clearance \> 60 mL/min/
* AST/ALT \< 2 times upper limit of normal (ULN)
* Total bilirubin \< 2 times ULN
* LVEF ā„ 45%
* No prior history of cancer
* Not pregnant or nursing
* Negative pregnancy test
PRIOR CONCURRENT THERAPY:
* Patients who have undergone radiation therapy after initial surgery are eligible but must have evaluation for metastatic disease within 2 weeks of starting chemotherapy
* No prior chemotherapy
What they're measuring
1
Efficacy in terms of long-term disease-free survival