Prednisone or Dexamethasone in Newly Diagnosed, Previously Untreated Primary Immune Thrombocytopenic Purpura

Inclusion criteria * Signed written informed consent according to IGH/EU/GCP and national local laws * Newly diagnosed untreated ITP adult patients * Age \> 18 \< 80 years * Platelet count \<20x109/L * Platelet count \> 20 x109/L and \<50x109/L plus bleeding with score \> 8 (according to grading scale at paragraph 7.1) * Baseline Quality of Life evaluation questionnaire filled in Newly diagnosed untreated ITP adult patients * Age \> 18 \< 80 years * Platelet count \<20x109/L * Platelet count \> 20 x109/L and \<50x109/L plus bleeding with score \> 8 (according to grading scale at paragraph 7.1) * Baseline Quality of Life evaluation questionnaire filled in Exclusion criteria * Active malignancy at time of study entry * Steroids administration (PDN \<1mg/Kg/day) for more than 5 days before randomization * Concomitant treatment with anti-platelet and or anti-coagulant drugs * Concomitant severe psychiatric disorders * Not confirmed diagnosis of ITP for * \*Positivity of autoimmunity markers: antinucleus (≥1:80), anti-tireoglobulin, anti-tireoperoxidase, anti-cardiolipin (≥ 40 GPL UmL), anti-b2glycoprotein (≥ 40 IgG U/mL) antibodies, Lupus Anticoagulant (KCT ratio, dRVVT ratios ≥1.5 times the upper normal limit ), direct antiglobulin test (DAT ). * Presence of autoimmune hemolytic anemia * Presence of connective tissue disease * Women who are pregnant or breastfeeding * Cardiovascular diseases requiring treatment * Severe non-controlled, despite therapy, hypertension and…