Effectiveness of Human Rotavirus Vaccine, Rotarix™ Against Rotavirus Severe Gastroenteritis (RV SGE) in Infants

Inclusion Criteria: Inclusion criteria for surveillance subjects * A male or female child aged \< 60 months at the time of admission (a child becomes ineligible on the day of its fifth birthday). * Subject admitted with acute GE as an inpatient to the study site during the study period. * Written informed consent obtained from the parent or guardian of the subject. Selection criteria for cases Cases will be limited to those surveillance subjects: * who are born after 1 November 2005 (date of availability of Rotarix™ vaccination in Singapore), * who are aged at least 16 weeks at the time of hospital admission. * whose stool samples are tested positive for RV. Selection criteria for controls All controls must satisfy the following criteria at study entry: * Admitted for acute disease with non-GE causes in the same hospital as the case , with the closest admission date to the cases. * Aged at least 16 weeks at the time of hospital admission. * Born within a range of ± 2 weeks from the date of birth of cases. In case there is no suitable match, then the range would be extended to ± 4 weeks. * Written informed consent obtained from the subject's parents/guardians. Exclusion Criteria: For enrolment of surveillance subjects The following criteria should be checked at the time of study entry. If any apply, the subject must not be included in the study: * The diagnoses at admission to the study site do not include acute GE. * Children for whom stool samples are not available…