Botulism Antitoxin Effects on Paralysis Induced by Botulinum Neurotoxins in the EDB Muscle

Inclusion Criteria: * Male or female * Age 18 - 55 years * Body-mass index 19-30 * Normal and healthy as determined by medical history, physical examination, ECG, NCS, vital signs and tests of liver, kidney and hematological functions * Adequate form of contraception for female subjects * For women with child-bearing potential-using hormonal contraception (oral, injectable or implant) continuously for 3 months prior to the start of the study and willing to continue to use hormonal contraception throughout the entire study. IUD inserted or use of condoms for at least 2 months prior to dosing * Other forms of contraception may be considered as adequate at physician's discretion * Surgically-sterilized female subjects * For female subjects who are postmenopausal, an FSH ≥ than 40 mIU/mL must be obtained. If the FSH is \< 40 mIU/mL the subject must agree to use an acceptable form of contraception (see above for acceptable forms of contraception) * Signed written Informed Consent Exclusion Criteria: * Previously injected with BOTOX®, BOTOX® COSMETIC or MYOBLOC® * Any known or documented Botulinum infection/intoxication * Any known or documented allergies to horses (e.g. rash, wheezing, rhinitis etc. after exposure to horses) * Any known or documented allergies to horse serum (observation of adverse events after treatment with any kind of product containing horse serum) * Any moderate or severe food allergies, seasonal allergies or hay fever requiring treatment with per…