Radiation Therapy in Treating Patients Who Have Undergone Surgery for Newly Diagnosed Grade II or… (NCT00626730) | Clinical Trial Compass
UnknownPhase 2
Radiation Therapy in Treating Patients Who Have Undergone Surgery for Newly Diagnosed Grade II or Grade III Meningioma
Switzerland78 participantsStarted 2007-12
Plain-language summary
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Giving high-dose radiation therapy after surgery may kill any tumor cells that remain after surgery.
PURPOSE: This phase II trial is studying radiation therapy to see how well it works in treating patients who have undergone surgery for newly diagnosed grade II or grade III meningioma.
Who can participate
Age range18 Years – 70 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
DISEASE CHARACTERISTICS:
* Histologically confirmed newly diagnosed meningioma, including the following subtypes:
* Atypical WHO grade II meningioma greater than or equal to 4 mitosis per high-power field \[HPF\] or the presence of at least 3 of the following variables:
* Cellularity
* Architectural sheeting (i.e., patternless pattern)
* Macronuclei cell formation
* Small cell formation
* Malignant WHO grade III meningioma
* All locations allowed except for optic nerve sheets tumors
* Complete or subtotal resection as assessed by the surgeon after verification with a postoperative MRI and according to Simpson guidelines
* No neurofibromatosis type 2 (NF-2)
PATIENT CHARACTERISTICS:
* WHO performance status 0-2
* Not pregnant or nursing
* Fertile patients must use effective contraception during study therapy
* May be registered on this trial only once
* No clinical evidence of second malignancies except carcinoma in situ of the cervix or basocellular carcinoma
* No psychological, familial, sociological, or geographical condition potentially hampering compliance with the study protocol and follow-up schedule
PRIOR CONCURRENT THERAPY:
* No prior radiotherapy to the brain or meninges interfering with the protocol treatment plan
What they're measuring
1
Progression-free survival
Trial details
NCT IDNCT00626730
SponsorEuropean Organisation for Research and Treatment of Cancer - EORTC