MT2004-30: Tomotherapy for Solid Tumors (NCT00623077) | Clinical Trial Compass
TerminatedPhase 1
MT2004-30: Tomotherapy for Solid Tumors
Stopped: Replaced by another study
United States23 participantsStarted 2005-08
Plain-language summary
RATIONALE: A peripheral blood stem cell transplant or bone marrow transplant using stem cells from the patient may be able to replace immune cells that were destroyed by chemotherapy and image-guided intensity-modulated radiation therapy used to kill tumor cells.
PURPOSE: This phase I trial is studying the side effects and best dose of bone marrow radiation therapy followed by an autologous stem cell transplant in treating patients with high-risk or relapsed solid tumors.
Who can participate
Age range70 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Diagnosis Patients must have had histologic verification of malignancy at original diagnosis. Diseases included are:
* Ewing's Family Tumors (ES/PNET/DSRCT): metastatic at the time of diagnosis and/or relapsed after therapy
* Renal tumors: relapsed (all histology-Wilm's tumor) or at diagnosis (clear cell sarcoma and Rhabdoid tumor),
* Hepatoblastoma: metastatic at the time of diagnosis and/or relapsed after therapy
* Rhabdomyosarcoma: metastatic at the time of diagnosis and/or relapsed after therapy
* Soft tissue sarcomas: chemotherapy responsive metastatic disease or chemotherapy responsive relapsed disease
* Primary Malignant Brain Neoplasms at diagnosis and/or relapse
* Retinoblastoma: disseminated at diagnosis and/or relapsed
* Other High Risk Metastatic or Relapsed Solid Tumors: To be approved by two or more physicians on the study committee
* Disease Status: Patients must have either: 1) no evidence of disease or 2) stable, non-progressive disease (defined as non-progressive abnormalities on physical exam or computated tomography (CT) and/or magnetic resonance imaging \[MRI\]) within 4 weeks of study entry.
* Age: Patients must be 0-70 years of age at the time of study entry.
* Performance Level: Karnofsky \> or = 50% for patients \> 10 years of age and Lansky \> or = 50% for patients \< or = 10 years of age. Note: Neurologic deficits in patients with central nervous system (CNS) tumors must be stable for a minimum of 1 week prior…
What they're measuring
1
Maximum tolerated dose of tomotherapy up to 12 Gy
Timeframe: Day 42
Trial details
NCT IDNCT00623077
SponsorMasonic Cancer Center, University of Minnesota