Ziprasidone in Pediatric Bipolar Disorder

Inclusion Criteria: * Outpatients aged 10-17 years * Currently meet Diagnostic and Statistical Manual of Mental Disorders IV-Text Revision (DSM-IV-TR) criteria for bipolar disorder, type I, II or Not Otherwise Specified (NOS) as determined by the Schedule for Affective Disorders and Schizophrenia -Present/Lifetime (Kiddie-SADS-PL) * Experiencing manic, hypomanic or mixed states as determined by clinical diagnosis and Kiddie- Young Mania rating scale (K-YMRS) equal to or more than 14 * General good health as determined by medical history, physical examination, and laboratory evaluations * Female adolescents, if sexually active, must practice birth control methods approved by the primary investigator * Ability to swallow tablets * Subject's parent or guardian must be fully capable of monitoring the subject's disease process and compliance to treatment * Parent(s) or legal guardian(s) must read and sign the informed consent form after the nature of the study has been fully explained and assent must be obtained from subjects. Exclusion Criteria: * Have a lifetime DSM-IV-TR Axis I disorder diagnosis of autistic disorder, schizophrenia, schizoaffective disorder, or other psychotic disorders * DSM-IV-TR diagnosis of alcohol or substance abuse or dependence within the past 6 months * Serious or unstable medical or neurological conditions which require concomitant medications * Judged by the principal investigator (PI) to be acutely suicidal or homicidal, or at imminent risk of inj…