Safety and PK of Nikkomycin Z for Coccidioides Pneumonia Treatment

Inclusion Criteria: * Age \>= 18 years and \<= 50 years * Male or Female (if female, must have a negative pregnancy test and agree to use an acceptable contraception method) * Able to understand study and give written informed consent * Have a respiratory illness with at least one of the following: Cough, chest pain dyspnea or tachypnea, sputum production, or fever/chills/night sweats * Have a new or suspected new pulmonary infiltrate on Chest X-ray * Have a positive coccidioidal serology by EIA or immunodiffusion Exclusion Criteria: * Patients under the age of 18 years or over 50 years * Patients with a prior history of confirmed coccidioidal infection * Laboratory diagnosis of another etiology for the inclusion-defining illness * Inability to comprehend study and provide informed consent * History of or current evidence of major organ disease * Concomitant use of prednisone and other corticosteroids not permitted * Concomitant immunosuppressive therapy is not permitted * Concomitant antibacterial therapy is not permitted