A Study to Evaluate the Effectiveness and Safety of Tapentadol (CG5503) in the Treatment of Acute Pain From Bunionectomy.

Inclusion Criteria: * Patients must undergo primary unilateral first metatarsal bunionectomy * Pain intensity must be moderate to severe following removal of a continuous popliteal sciatic block * Female patients must be postmenopausal, surgically sterile, or practicing an effective method of birth control if they are sexually active. Exclusion Criteria: * Patients will be excluded from the study if they have a history of seizure disorder or epilepsy * History of malignancy within the past 2 years before starting the study * History of alcohol or drug abuse * Evidence of active infections that may spread to other areas of the body * Clinical laboratory values reflecting severe renal insufficiency * Moderately or severely impaired hepatic function * Currently treated with anticonvulsants, monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants (TCAs), neuroleptics, or serotonin norepinephrine reuptake inhibitor (SNRI).