Effectiveness of Flutamide in Treating Women With Premenstrual Dysphoric Disorder

Inclusion Criteria: * Meets DSM-IV criteria for PMDD by history * Regular menstrual cycles that are 25 to 35 days in length during the year prior to study entry * Willing to use barrier methods of birth control during the study if sexually active * If engaged in psychotherapy for at least 3 months before study entry, participation will be allowed if the intensity of psychotherapy remains the same during the study * Normal PAP and physical exam, including pelvic exam, within the 1 year prior to study entry Exclusion Criteria: * Use of oral contraceptives or other exogenous hormone preparations within the 3 months prior to study entry * Suicide attempt or severe suicidal ideation within the 2 years prior to study entry * History of any psychotic disorder or bipolar disorder * Substance abuse, except nicotine, within the 6 months prior to study entry * Use of pharmacological treatment for PMDD symptoms (e.g., antidepressants, hormones, gonadotropin-releasing hormone agonists, anxiolytics, calcium, herbal preparations, diuretics) within the 3 months prior to study entry * Daily use of psychotropic or anticonvulsant medications within the 3 months prior to study entry * Use of sleeping pills more than once per week * Consumption of more than 50 ounces of alcohol per week * Pregnant or breastfeeding * Hepatic, renal, autoimmune, or chronic inflammatory disease * Seizure disorder * Inability to read or follow instructions in English