RATIONALE: Giving chemotherapy and total-body irradiation before a donor peripheral blood stem cell transplant helps stop the growth of cancer cells. It also stops the patient's immune system from rejecting the donor's stem cells. The donated stem cells may replace the patient's immune cells and help destroy any remaining cancer cells (graft-versus-tumor effect). Sometimes the transplanted cells from a donor can also make an immune response against the body's normal cells. Giving tacrolimus, sirolimus, antithymocyte globulin, and methotrexate before and after transplant may stop this from happening. PURPOSE: This phase II trial is studying how well sirolimus, tacrolimus, and antithymocyte globulin work in preventing graft-versus-host disease in patients undergoing a donor stem cell transplant for hematological cancer .
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Cumulative Incidence of Grade II-IV Acute Graft-Versus-Host Disease (GVHD) at Day 100
Timeframe: 100 Days Post Hematopoietic Stem Cell Transplant (HSCT)
Severity of Acute GVHD
Timeframe: 100 Days Post HSCT
Cumulative Incidence of Chronic GVHD
Timeframe: 2 year point estimate was provided.
Severity of Chronic GVHD
Timeframe: Patients were evaluated until they developed chronic GVHD, a median of 130 days post HSCT