Thymus Transplantation With Immunosuppression

Transplant Inclusion * No age limit * Thyroid studies must be done and if abnormal, must be on therapy DiGeorge diagnosis - must have 1 symptom from the following list: * Heart defect * Hypocalcemia requiring replacement * 22q11 hemizygosity * 10p13 hemizygosity * CHARGE association * Abnormal ears plus mother with diabetes (type I, type II, or gestational) Atypical Diagnosis: * Must have, or have had, a rash. If rash present, biopsy of rash must show T cells in skin. If rash \& adenopathy resolved, must still have oligoclonal T cells. * Within 1 month of tx must have PHA response \>20 fold above background or \>5,000 cpm, whichever is higher, or response can be \< this. * Circulating CD3+ T cells \>50/mm3 but CD45RA+CD62L+CD3+ T cells \<50/mm or \<5% of CD3 count, whichever is higher (must be done 2x) * Immunoscope with \>40% oligoclonal TCRBV families. A 2nd test per sponsor discretion if T cell numbers increase or activation status changes. * If TREC done pre-tx must have TRECs \<100 per 100,000 CD3+ cells. Typical Diagnosis: * Circulating CD3+ CD45RA+ CD62L+ T cells and \<50/mm3 or \<5% of total T cells * PHA response \>20 fold above background or \>5,000 cpm, whichever is higher. * 2 studies must show similar immunological findings qualify for this study. * TRECs, if done, should be \<100/100,000 CD3 cells Transplant Exclusion: * Heart surgery \<4 weeks pre-tx date * Heart surgery anticipated w/in 3 months of proposed tx * Rejection by surgeon or anesthesiologis…