Percutaneous Removal and Margin Ablation for Breast Cancer

Inclusion Criteria: * Female, 18 to 90 years of age * Non-pregnant, not breastfeeding * Pre-study documentation of: * Size ≤1.5 cm cancer successfully removed by US-guided IVEB within 30 days of registration * Uni-centricity, unilateral cancer by radiology (mammogram and MRI) * Location of abnormality \> 1 cm from the skin * Ductal Carcinoma, Invasive (Grade I-III) or In-Situ * No palpable axillary or supraclavicular lymph nodes * Good general health * Zubrod Performance Status of 0, 1, or 2 * If prior non-breast malignancy, must have 5 year disease-free survival * No prior chemotherapy * Hormonal therapy must be stopped * Therapy with tamoxifen must have been of 14 days or less duration Exclusion Criteria: * Subjects less than 18 years of age or greater than 90 years of age * Pregnant or breastfeeding * Male * Prior Breast Biopsy affected breast * Breast implants * Multicentric disease, bilateral disease * Residual disease after IVEB of \> 1cm on MRI * Lesions \> 1.5 cm in diameter * Lesions \< 1 cm from skin surface * Previous radiation therapy to the breast