Bupropion in the Treatment of Methamphetamine Dependence

Inclusion Criteria: * patient in the substance use disorder program at either the Omaha VA Medical Center or at Catholic Charities Campus for Hope * diagnosis of methamphetamine dependence as well as presence or history of psychosis based on the Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM-IV) criteria (not to include patients in full sustained remission) * provide names, addresses, and phone numbers of at least two collateral informants who can provide information on their methamphetamine and other drug use during follow-up * must sign an informed consent as approved by the UNMC Internal Review Board (IRB) and Catholic Charities Research Committee. Exclusion Criteria: * a history of severe injury to their brain * advanced cardiac, pulmonary, renal or liver disease * predisposition to seizures * history of bulimia or anorexia nervosa * current diagnosis of major depressive disorder * diagnosis or past history of panic disorders, schizophrenia, or bipolar affective disorder * family history or childhood history of epilepsy or seizures * history of strokes, brain tumors, or bleeding in the brain. * used any psychoactive drug within one week of study entry (two weeks for MAO (monoamine oxidase) inhibitors or protriptyline, four weeks for fluoxetine) * currently using any theophylline product (e.g. Theodur) * used an investigational drug in any study within the past four weeks * used a therapeutic course of bupropion SR for \> 1 week at any time in…